A COMPRESSIVE REVIEW ON TAXOL: OCCURRENCE, ISOLATION AND CHARACTERISTIC FEATURES
*Jasna T. J., Surya S. Nair and Jesvy Joby
ABSTRACT
Paclitaxel, another name for Taxol, is a popular chemotherapy drug used to treat a variety of malignancies. One of the most often used antitumor medications; Taxol has been used to treat more than a million patients since its antitumor activity was discovered. First, taxol was extracted from a Taxus brevifolia tree. It is one of the most prized natural substances that the Food and Drug Administration (FDA) in the USA has authorized for the treatment of many forms of cancer. In addition, the overuse of this natural tree species and its decreased taxol yield prompted researchers to look into other sources, such as semi-synthetic methods and other Taxus species. A better way to isolate taxol and its analogues from a crude extract of the Taxus plant is by using reverse phase liquid chromatography. In this method, Taxol and its analogues stick to its adsorbent, and then the eluent is used to wash them off, allowing Taxol and its natural analogues to be collected from the material.
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