Abstract

Chidiebere Sandra Okoroigwe, D. C. Nwosu. U.C Edward, Deborah Orji, Nwamaka Egbeonu, Chioma Ukaga and Emmanuel Ifeanyi Obeagu*

ABSTRACT

The study population comprised 50 men diagnosed with prostate cancer by biopsy within the age bracket of 40 -80 years and 50 matched apparently healthy men without prostate cancer served as control. The prostate cancer subjects were sub divided into 25 subjects on androgen deprivation therapy and 25 treatment naïve subjects. Blood samples were collected aseptically by a phlebotomist and dispensed into plain tubes. The sera obtained were analyzed by standard methods following the manufacturer’s standard operating procedure and data obtained was analyzed using Statistical Package for Social Science (SPSS) version 23. The test of significance was determined by student t-test. Values were expressed as Mean ± standard deviation. Pearson correlation was also determined and values with P<0.05 were considered statistically significant. The result showed significantly lower mean levels of glutathione peroxidase, superoxide dismutase, uric acid, (p=0.000 for all) in prostate cancer subjects (261.35 ± 47.90 U/L, 141.34 ± 21.28 U/mL, 4.78 ± 0.44 mg/dl, respectively ) compared to control subjects (422.30 ± 14.44 U/L, 194.83 ± 9.21 U/mL, 7.04 ± 0.82 mg/dL respectively). There was a significant higher level of vitamin E (p=0.000) in prostate cancer subjects (11.95 ± 2.41 μg/mL respectively) compared to control subjects (6.70 ± 0.74 μg/mL respectively).