Abstract

Sahana K.*, Chandanam Sreedhar, Harsha K. Tripathy, T. Srinivasa Rao, Manju S.V. and Nanditha M.M.

ABSTRACT

Dapagliflozin and vildagliptin are two broad classes of anti-diabetic glycoside pharmacological ingredients for the management of -2-disaccharides. Dapagliflozin, an SGLT-2 inhibitor, lowers blood sugar levels by increasing glucose urinary excretion while vildagliptin could be a DPP-4 inhibitor which increases insulin secretion and suppresses glucagon secretion. The accurate evaluation and quality assurance of these pharmaceuticals are vital to ensure their effectiveness and safety in pharmaceutical formulations. This encapsulates the various methods of analysis that are developed and validated for the determination of dapagliflozin and vildagliptin in bulk and in dosage form. RP-HPLC Chromatography and UV-VIS Spectroscopy have been used for this purpose. The differences between these methods have been described with respect to sensitivity, specificity, and relevance in drug testing. The reason for this review is to provide information on the analytical methods developed for dapagliflozin and vildagliptin and to help scientists and practitioners in the pharmaceutical industry choose the right methods for quality control testing.