COMPREHENSIVE CONTEMPLATIONS FOR ADVANCED EXPLANATORY STRATEGIES: LISINOPRIL AND HYDROCHLOROTHIAZIDE
Nanditha M. M.*, Harsha K. Tripathy, Chandanam Sreedhar, T. Srinivasa Rao, Manju S. V. and Sahana K.
ABSTRACT
The most used combination in the treatment of hypertension is hydrochlorothiazide and lisinopril. For efficacy and safety in treating hypertension, precise measurement of lisinopril (LIS) and hydrochlorothiazide (HCTZ) in pharmaceutical formulations is required. Different analytical methods are investigated in this research for their simultaneous estimation, such as spectroscopic (UV-Vis), fluorimetric, and chromatographic (HPLC, RP-HPLC, and HPTLC) methods. For everyday analysis, more affordable UV-Vis spectrophotometry is a better choice, although RP-HPLC is the best method due to its high sensitivity and precision. The greater sensitivity of fluorimetric methods makes them useful for the determination of trace levels of drugs. Green analytical methods and LC-MS are future opportunities that may enhance pharmaceutical quality control and provide accurate and long-term medication analysis.
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