Abstract

*Lekhana Dodmatt S R., Spandana A., Arpitha S., Dr. Hanumanthachar Joshi, Dr. Nagendra R., Dr. Bilal K. V.

ABSTRACT

Cholelithiasis is a prevalent condition that is often treated with laparoscopic cholecystectomy due to its shorter recovery time and fewer complications. Postoperative issues like pain management and ADRs may still arise. Propofol is an excellent anaesthetic with rapid onset and recovery, but its role in analgesia and recovery requires further investigation. Factors such as age, co- morbidities, and psychosocial status may influence postoperative recovery and overall patient satisfaction. Materials and Methods: A prospective observational study was conducted in the surgery department of Krishna Rajendra Hospital, Mysuru. The study included patients undergoing laparoscopic cholecystectomy, of either gender, who received propofol anaesthesia. These patients were analysed for hemodynamic stability, recovery profile, pre-operative and post- operative pain, and the prevalence, causality and severity of adverse drug reactions associated with propofol anaesthesia. Results: A total of 111 patients were included with more predominance among females. Most patients were diagnosed with cholelithiasis (95.49%). 96.39% of patients had pre-operative systolic blood pressure between 91-140 mmHg, with similar results observed post-operatively. 81.98% of patients had diastolic blood pressure between 61-80 mmHg pre- operatively with 78.38% post-operatively. Pulse rates were stable, with 64.86% of patients having a pre-operative pulse rate of 81-100 bpm. A Propofol dose of 100 mg was given to 67.56% of patients. Adverse drug reactions were occurred in 72.07% of patients, with tachycardia being the most common (16.25%). Majority of ADRs were mild (65%), and 87.5% were categorized based on the Naranjo Scale. Conclusion: This study examined the effects of propofol anesthesia on pain management and recovery in patients undergoing laparoscopic cholecystectomy. Results indicated that propofol effectively reduced postoperative pain and led to quicker recoveries. Most adverse drug reactions (ADRs) were mild to moderate, highlighting the importance of individualized anesthesia protocols and continuous monitoring to enhance patient safety and outcomes.