Abstract

Chetan Ghulaxe*, Mousumi Karpillai, Sujit Pillai, Pankaj Kushwah, Ranu Mansare

ABSTRACT

Transdermal drug delivery system (TDDS) specialist are ongoing to explore for new method that can efficiently and painlessly transmit better molecules in therapeutic quantity to overcome the Difficulties allied with oral route, namely poor bioavailability due to first pass metabolism and receptiveness to produce rapid blood level. Transdermal drug delivery get improved the therapeutic effectiveness and security of drugs by more site specific way but spatial and temporal placement within body is necessary to reduce both the size and number of doses essential to achieve the objective of systemic medication through topical application to the intact skin surface. Transdermal patches deliver the drugs for systemic effects at a predetermined and controlled rate. Through a diffusion process, the drug enter the bloodstream directly though the skin. Since there is high concentration on the patch and low concentration in the blood, the drug will keep diffusing into the blood, the drug will keep diffusing into the blood for a long period of time, maintain the constant concentration of drug in the blood flow. TDDS is act as micro emulsion, Transdermal patches, Niosomes, Ethosome and liposomal drug delivery system is act as Novel approach of carrier mediated drug delivery system. The success of all the TDDS depends on the skill of the drug to permeate skin in sufficient quantities to achieve its desired therapeutic effect. This review article provides a detailed study of transdermal that is benefit, disadvantages, mechanism, factors affecting skin permeation and types. Characterization of transdermal patch is use to check its quality, size, time of onset & duration, adhesive property, thickness, weight of patch, moisture of content, uniformity & cutaneous toxicological studies.