Abstract

Dr. Sule O. J.*, Arhoghro E. M. and Erigbali P.

ABSTRACT

The study was to investigate the biochemical effect of ethanol extract of Mimosa pudica leaf in thioacetamide-induced albino rats by using liver and kidney serum marker enzymes. After the treatment scheduled period of 21 days, the extent of nephrotoxicity and hepatotoxicity with thioacetamide (400 mg/kg bwt.) was determined. Nephroprotective and hepatoprotective activity of ethanol extract of Mimosa pudica leaf was estimated from serum samples. In this study, we assess the serum creatinine, urea, bilirubin, AST, ALT and ALP using various standard kits. Administration of thioacetamide causes an increase in the level of creatinine, urea, bilirubin, ALT, AST and ALP, which are considered as the selective biomarkers of kidney and liver injury when compared with the normal control. The present study showed decrease in the elevated levels of these enzymes. Treatment with extract of Nimosa pudica at 200 and 400 mg/kg bwt. showed a dose dependent, significant decrease in creatinine, urea, bilirubin, ALT, AST and ALP (P<0.05) when compared with the thioacetamide control group. The histopathology findings supported the results. In conclusion, the results of this study showed that ethanol leaf extract of Mimosa pudica had nephroprotective and hepatoprotective activity against thioacetamide-induced nephrotic and hepatic injury in rats.