Abstract

Dr. Prashant Bedarkar*

ABSTRACT

Introduction- Nishamalaki or Nisha Amalaki representing various combination formulations of Turmeric (Nisha, Haridra, Curcuma longa L.) and Indian gooseberry (Amalaki, Emblica officinalis Gaertn.) is recommended in Ayurvedic classics, proven efficacious and widely practiced in the management i.e. treatment of Diabetes along with management and prevention of complications of Madhumeha (Diabetes). Aims and objectives-Inspite of many pharmacological, clinical researches of Nishamalaki on Glucose metabolism and Glycemic control, their review is not available, hence present study was conducted. Material and methods- Evidence based online published researches of Nishamalaki on Glucose metabolism and Glycemic control and its efficacy in the management of complications of Diabetes from available databases and search engines were referred for review through. Summary of published researches was systematically arranged, analyzed and presented. Observations and results-Review of online Published original research studies reveals total were found to be 13 in number, comprising of 3 in vitro studies and animal experimental pharmacological researches each and 7 clinical researches. Discussion and Conclusion- Nishamalaki is group of various combination formulations of Haridra and Amalaki. It is effective in the clinical management of Madhumeha, Prameha and Diabetes. Nishamalaki possess antihyperglycemic, Antidiabetic, insulinomimetic, ?-Amylase inhibitory and ?-glucosidase inhibitory, antioxidant properties. It improves insulin sensitivity, increases glucose uptake by skeletal muscles and is beneficial in the management of Madhumeha, Prameha and Diabetes as well as prevention of its complications microvascular- like diabetic nephropathy, neuropathy, retinopathy, gastropathy and macrovascular like atherosclerosis. Conclusion- Nishamalaki is group of various combination formulations of Haridra and Amalaki. It is effective in the clinical management as well as prevention of complications of Madhumeha, Prameha and Diabetes.