World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

SYNTHESIS AND ANTIMICROBIAL POTENTIAL OF THIAZOLIDIN-4-ONE DERIVATIVES

Rakesh Kumar and Shailendra Patil

ABSTRACT

A series of thiazolidin-4-one derivatives (TH1-T15) was synthesized and evaluated for their antimicrobial potential. Antimicrobial Activity was performed by Minimum Inhibitory Concentration (MIC) and zone of inhibition methods against Gram negative E. Coli, Gram positive bacteria: B. Subtilis, S. aureus, and fungal strains: A. niger and C. albicans. Among the synthesized derivatives, compounds 2, 10 and 14 was found to be most active against bacterial strains and compounds 6 and 12 was found to be most active against the fungal strains. In case of zone of inhibition, compounds 4, 5, 9 and 11 showed the good results against the tested strains. All the titled compounds (TH1-T16) were characterized by 1H NMR and IR spectral data.

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