Abstract

Ajkia Zaman Juthi* and Tasnim Zaman Bithi

ABSTRACT

The success of controlled oral drug deliveries is associated with some physiological adversities like short gastric residence time and unpredictable gastric emptying time. Although oral administration is often used for the drugs with poor oral bioavailability due to limited absorption or degradation in the GIT but still it is considered as the most convenient one. Prolonged gastric residence increases duration of drug release, reduces drug waste, and improves drug solubility in gastric pH. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. One of the promising systems is gastro retentive drug delivery system. Numerous techniques have been tried to retain the drug in the gastric media.